Popovic founded the Serbian nonviolent resistance group Otpor! which campaigned successfully against Serbian president Slobodan Milosevic was successful in October 2000. Otpor! would inspire thousands of protestors to take over the Serbian Parliament. Post revolution, Popovic would work as a team member of the Serbian National Assembly.
In 2003, Popovic along with a small group of others worked to create the Centre for Applied Nonviolent Action and Strategies (CANVAS). CANVAS has undertaken groundbreaking work with activists from 46 different countries, including Venezuela, Burma, Zimbabwe, and Iran, as well as working to spread knowledge of nonviolent strategies combined with tactics used by Otpor! Less than a decade later, in November of 2011 Popovic would find himself named one of the "Top 100 Global Thinkers" by Foreign Policy Magazine for his role in inspiring the Arab Spring protesters.
A year later, in 2012, Popovic was nominated for the Nobel Peace prize. In 2014, the World Economic Forum of Davos would list him as a “Young Global Leader”. Recently, he has published Blueprint for Revolution, which looks at nonviolent activism worldwide.